Treatment and Handling Severe Obesity-Related Comorbidities in Adolescents Through Exercise
Launched by UNIVERSITY OF LISBON · Jul 22, 2024
Trial Information
Current as of June 27, 2025
Not yet recruiting
Keywords
ClinConnect Summary
The THOR-X trial is designed to study how a personalized exercise program can help adolescents aged 13 to 18 years who are severely obese and facing related health issues like high blood pressure, fatty liver disease, and metabolic problems. The goal is to see if this exercise program can improve their weight, health conditions, and overall quality of life. In addition, the trial aims to understand how exercise interacts with any medications the participants might be taking and how it affects their daily habits.
To be eligible for this study, participants must be living in the Lisbon area, have a body mass index (BMI) that classifies them as severely obese, and have been receiving care at a Pediatric Obesity Clinic for at least six months. They should also have specific health issues related to obesity. Participants will not be able to join if they have serious medical conditions, are unable to exercise, or are pregnant, among other exclusions. Those who take part can expect to engage in a tailored exercise routine and contribute to a broader understanding of how to better support adolescents with obesity. Additionally, the study will create resources for healthcare providers to help them manage this population more effectively.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • adolescents aged 13 to 18 years;
- • of any gender (including transgender adolescents);
- • with severe obesity (≥3.0 BMI z-score) \[24\];
- • with any obesity-related comorbidity (e.g., hypertension, IR or DMT2, dyslipidemia, eating disorders, depression/anxiety);
- • at least 6 months of follow-up at the Pediatric Obesity Clinic (HSM, CHULN) at the time of recruitment;
- • living in Lisbon area;
- • informed consent/assent signature.
- Exclusion Criteria:
- • major or unstable clinical conditions (other than obesity or its related comorbidities);
- • inability to perform regular PA;
- • pregnancy;
- • mental disorders;
- • smoking habits;
- • being involved in another weight loss program.
About University Of Lisbon
The University of Lisbon, a leading academic institution in Portugal, is dedicated to advancing medical research and innovation through rigorous clinical trials. With a strong emphasis on interdisciplinary collaboration, the university harnesses the expertise of its renowned faculty and state-of-the-art facilities to conduct high-quality research aimed at improving patient outcomes. The institution is committed to ethical standards and regulatory compliance, ensuring that all trials are designed and executed with the utmost integrity. By fostering partnerships with healthcare providers and industry leaders, the University of Lisbon strives to contribute significantly to the global body of medical knowledge and therapeutic advancements.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported