Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-D )

Launched by BEIJING TIANTAN HOSPITAL · Jul 22, 2024

Keywords

ClinConnect Summary

The ESU-ACE-D trial is studying how patients with a specific type of stroke, called ischemic stroke, fare when treated in two different environments. One group of patients will receive care in a standard stroke unit that follows regular guidelines, while another group will be treated in a new Emergency Stroke Unit that uses advanced imaging technology to help make quicker decisions. The goal is to see which approach leads to better outcomes for patients who arrive at the emergency department between 4.5 to 6 hours after their symptoms first started.

To join this trial, you must be at least 18 years old and have symptoms of an ischemic stroke that started within the last 4.5 to 6 hours. You should also have a certain level of stroke severity, be eligible for a specific treatment called endovascular thrombectomy, and be able to give informed consent to participate. If you choose to take part, you can expect to receive specialized care based on the treatment group you are assigned to, with the hope that the findings from this trial will help improve stroke care in the future.

Gender

ALL

Eligibility criteria

• • 1. Age ≥ 18 years;
• • 2. Patients who arrive at the emergency department between 4.5-6 hours of symptom onset\* (\*Symptom onset is defined by the "last seen normal" principle);
• • 3. Presenting with ischemic stroke symptoms;
• • 4. Pre-stroke mRS score 0-1;
• • 5. Baseline NIHSS score ≥ 5;
• • 6. Eligible for endovascular thrombectomy;
• • 7. Informed consent signed.
• Exclusion Criteria:
• • 1. Baseline NIHSS score \< 5;
• • 2. Unable to undergo MRI because of claustrophobia;
• • 3. Patients with cardiac pacemaker/brain pacemaker/insulin pump implantation;
• • 4. Definite contraindication for endovascular thrombectomy;
• • 5. Patients with postictal hemiparesis (Todd's paralysis) or those with concomitant neurological/psychiatric conditions who are unable or unwilling to cooperate;
• • 6. Pregnant women, nursing mothers, or reluctance to use effective contraceptive measures during the period of trial;
• • 7. Participation in other interventional randomized clinical trials within 3 months before enrollment;
• • 8. Patients deemed unsuitable for participation in this trial by the investigator or those for whom participation in this trial may result in greater risks.