Protecting Autologous Free Flaps From Ischemia/Reperfusion Damage With Cold Storage.

Launched by UNIVERSITY OF CAGLIARI · Jul 23, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a new method to help protect tissue flaps used in reconstructive surgery from damage that can occur when blood flow is temporarily stopped (a condition called ischemia) and then restored (reperfusion). The researchers believe that storing these flaps in a cold solution may reduce the risk of complications after surgery. The study will focus on patients undergoing reconstructions after cancer treatment, such as for the jaw, breast, or soft tissues in the head and neck.

To be eligible for this trial, patients should be undergoing specific types of reconstructive surgery, including those who need flaps from the fibula (a leg bone), ALT (an area of the thigh), or DIEP and PAP (areas used in breast reconstruction). Unfortunately, those with certain health issues, like malnutrition or connective tissue diseases, cannot participate. Participants will have their blood flow monitored during surgery and will be evaluated afterward to see how well they recover, especially in terms of sensation and dental rehabilitation. This study aims to improve outcomes for patients undergoing these important surgeries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Post-oncological mandible reconstruction through fibula free flap,
• • Post-oncological soft tissue reconstruction through ALT (Anterior Lateral Thigh) free flap in head and neck region
• • Post-oncological breast reconstruction through DIEP (Deep Inferior Epigastric Perforator) and PAP (Profunda femoris Artery Perforator) free flaps.
• Exclusion Criteria:
• • Malnutrition
• • Malabsorption
• • Vasculitis
• • Pathologies of the connective tissue