Efficacy, Tolerability, and Cognitive Effects of Deep Transcranial Magnetic Stimulation for Bipolar Depression

Launched by TIANJIN ANDING HOSPITAL · Jul 23, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called deep transcranial magnetic stimulation (dTMS) to see if it can help improve symptoms of bipolar depression. The goal is to find out if dTMS can not only reduce feelings of depression but also enhance thinking and memory skills in people who have not responded well to traditional medications. The trial is currently looking for participants, and anyone between the ages of 18 and 65 who has been diagnosed with bipolar depression and has not seen improvement from their medication might be eligible to join.

If you decide to participate, you would undergo dTMS treatment, which is a non-invasive procedure that uses magnetic fields to stimulate certain areas of the brain. It’s important to note that you cannot have any metal implants near your head or have certain medical conditions, like uncontrolled epilepsy or serious psychiatric issues. Before starting, you would need to read and sign a consent form to confirm that you understand the study and agree to participate. This study offers a chance to explore a new treatment option and contribute to research that could help others with bipolar depression.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Confirmed diagnosis of bipolar depression;
• • Met standardized criteria for failure to achieve remission from pharmacological treatment in the current illness episode;
• • Pharmacological treatment maintained unchanged for the four weeks preceding rTMS application；
• • Able to read, verbalize understanding and voluntarily sign the informed consent form prior to performance of any study-specific procedures or assessments
• Exclusion Criteria:
• • Previous treatment with rTMS;
• • Ferromagnetic material close to the head;
• • Cardiac pacemaker and/or implanted electronic device;
• • The presence of neurological disorders (uncontrolled epilepsy, previous significant head injuries, brain surgery);
• • Pregnancy or lactation;
• • Significant medical and/or psychiatric comorbidities;
• • Substance abuse in the last three months (not including caffeine or nicotine);
• • Acute psychosis;
• • Acute suicidality;
• • Patient refuses to sign consent for participation in the study