Efficacy of Topical 85% TCA in the Treatment of LSIL After Low-grade Abnormality of Screening Test: a Randomized Controlled Trial
Launched by DEPARTMENT OF MEDICAL SERVICES MINISTRY OF PUBLIC HEALTH OF THAILAND · Jul 24, 2024
Trial Information
Current as of June 26, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
The study aims to determine the efficacy and HPV clearance of an application of 85% TCA compared to placebo in the treatment of LSIL. This study will be conducted in women aged 18-65 years with colposcopic-biopsy proved HPV or CIN1, have low grade abnormalities of precolposcopy cervical screening. Low grade abnormalities include ASC-US+HPV positive, LSIL, HPV 16/18, persistent high-risk HPV infection. In patients referred to the colposcopy clinic with ASC-US without HPV testing, they will be eligible if the HPV testing later performed is positive for high risk type. The study will test whet...
Gender
FEMALE
Eligibility criteria
- • Inclusion criteria
- • Women, 18-65 years of age, colposcopic biopsy confirmed CIN1 or HPV (LSIL) preceded by low-grade cervical screening test, i.e. ASCUS HPV positive, LSIL, HPV 16/18 positive, persistent high-risk HPV infection.
- • Willing to participate in this trial
- • Exclusion criteria
- • Women diagnosed with previous or concurrent invasive carcinoma of the cervix
- • Women with history of pelvic radiotherapy
- • Pregnant women
About Department Of Medical Services Ministry Of Public Health Of Thailand
The Department of Medical Services, under the Ministry of Public Health of Thailand, is dedicated to advancing healthcare through rigorous clinical research and innovative medical practices. As a key sponsor of clinical trials, the department aims to enhance public health outcomes by evaluating new treatments, improving healthcare delivery, and ensuring the safety and efficacy of medical interventions. With a commitment to ethical standards and scientific integrity, the department collaborates with various stakeholders to address critical health challenges and promote evidence-based practices within the Thai healthcare system.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Thailand, Bangkok, Thailand
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported