Local Ischemic Postconditioning in Acute Ischemic Stroke

Launched by SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE'S HOSPITAL · Jul 27, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new approach called local ischemic postconditioning for patients who have suffered an acute ischemic stroke (AIS). The goal is to find out how safe this method is and what the best way to apply it is after a successful procedure to remove a blood clot from the brain (called mechanical thrombectomy). During this process, doctors will temporarily stop blood flow to the brain and then allow it to return intermittently. This might help the brain tissue recover better after being deprived of blood.

To participate in this trial, you must be at least 18 years old and have symptoms of an acute stroke affecting the front part of your brain. You should also have a specific level of stroke severity and be able to start treatment quickly after the stroke occurs. Participants will receive careful monitoring and follow-up care to assess their recovery. If you or a loved one are considering joining this trial, it's essential to discuss all eligibility criteria and potential benefits with your healthcare provider.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years old
• • Presenting with symptoms and signs consistent with acute anterior circulation ischemic stroke
• • Pre-stroke modified Rankin Score 0-1
• • Baseline National Institute of Health Stroke Scale (NIHSS) score≥6
• • Endovascular treatment can be initiated (femoral puncture) within 24 hours from stroke onset (stroke onset time is defined as last known well time)
• • Occlusion of the intracranial internal carotid artery, or the middle cerebral artery (MCA) (M1 or M2) and is the culprit artery
• • Ischemic core volume is \< 70 ml, mismatch ratio is \>1.8 and mismatch volume is \>15 ml as determined by CT perfusion imaging
• • Embolism verified as the etiology of occluded artery and modified Thrombolysis in Cerebral Infarction Score (mTICI) 2b or 3 achieved after mechanical thrombectomy.
• • Time from CT perfusion to reperfusion \< 2 hours
• • Informed consent signed
• Exclusion Criteria:
• • Stenosis of the proximal middle cerebral artery, internal carotid artery, or common carotid artery (≥50%) of the culprit artery
• • Evidence of internal carotid artery lesion that precludes the access and application of balloon guide catheter
• • Multiple vascular embolism on different pathways (e.g., bilateral MCA occlusions, or an MCA and a basilar artery occlusion)
• • Pre ischemic stroke within past 3 months
• • The expected survival time is less than 6 months, could not be followed at 90 days (such as patient with malignant tumor)
• • Currently pregnant, mental disease, advanced hepatic and renal insufficiency, severe heart failure
• • Participation in other interventional randomized clinical trials that may confound the outcome assessment of the trial
• • Other circumstances that the investigator considers inappropriate for this trial