Evaluation of Clinical Decision Support in Opioid Tapering
Launched by UNIVERSITY OF COLORADO, DENVER · Jul 24, 2024
Trial Information
Current as of June 26, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is studying how a special support tool can help doctors safely reduce the amount of opioids (pain medications) patients are taking. The goal is to follow the latest guidelines from the CDC, which suggest that patients should lower their opioid doses slowly to avoid withdrawal symptoms and reduce the risk of overdose. In the trial, doctors will be divided into two groups: one group will receive reminders to use the support tool when tapering a patient’s medication, while the other group will not receive these reminders. The researchers will look at how well each group follows the guidelines for tapering and whether there are any long-term effects on patients, like overdose or poisoning.
To be part of this study, you need to be a primary care patient currently taking opioids and must have been on your prescription for more than three months. You should also be taking a high dose or be using opioids along with another medication called benzodiazepines. However, if you are under 12, over 89, have had cancer recently, are in hospice or palliative care, or have sickle cell disease, you won't be eligible to participate. The study will last about 18 months, and during this time, participants will be monitored through their health records to see how well the tapering process works.
Gender
ALL
Eligibility criteria
- Inclusion Criteria: Primary care patients being tapered from an opioid. Tapering patients:
- • Have an active opioid prescription for more than 3 months and
- • Prescribed more than 90 morphine milligram equivalents (MME) per day or
- • Co-prescribed an opioid and benzodiazepine or
- • Received a reduction in opioid dosage by more than 5% MME per day
- Exclusion Criteria:
- • Patients \<12 and \>89
- • Patients with active cancer diagnosis in last 1 year
- • Patients with hospice care/palliative care order
- • Patients with sickle cell disease diagnosis
About University Of Colorado, Denver
The University of Colorado, Denver, is a leading academic institution dedicated to advancing medical research and improving healthcare outcomes. With a strong emphasis on innovation and collaboration, the university conducts a diverse range of clinical trials aimed at addressing critical health challenges. Its research initiatives are supported by a multidisciplinary team of experts, state-of-the-art facilities, and a commitment to ethical standards and patient safety. By fostering partnerships with local and global communities, the University of Colorado, Denver, strives to translate scientific discoveries into meaningful advancements in clinical practice and public health.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Trial Officials
Jason Hoppe, DO
Principal Investigator
University of Colorado, Denver
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported