Choline and Iron Deficiency

Launched by UNIVERSITY OF MINNESOTA · Jul 24, 2024

Keywords

ClinConnect Summary

This clinical trial, called "Choline and Iron Deficiency," is studying how a nutrient called choline can help improve brain development in infants with iron deficiency anemia. Iron deficiency anemia is a condition where there isn't enough iron in the body, which is essential for healthy growth and brain function. The researchers believe that giving infants with this condition both iron and daily choline supplements for nine months could lead to better memory and brain function compared to those who only receive iron with a placebo (a non-active treatment).

To be eligible for this trial, infants must be around 6 months old and have specific blood test results indicating iron deficiency anemia. They also should not have severe malnutrition or certain medical conditions that could affect their development. If a child is accepted into the study, their parents can expect regular check-ups and tests to monitor their progress over the nine months. This trial is important because if choline proves beneficial, it could be added to standard treatments for iron deficiency anemia, helping to prevent long-term brain issues in children.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 6 months +/- 28 days
• • Hb \< 11.0 g/dL
• • ZPP \> = 80
• • T\<37.5°C
• • Malaria-negative based on Rapid Diagnostic Test (RDT)
• • Mother is HIV-negative.
• Exclusion Criteria:
• • Developmental disorder
• • Severe malnutrition (severe wasting or bipedal edema)
• • Known sickle cell disease
• • Neurologic disorder, brain injury, or other condition affecting brain development
• • Not currently breastfeeding
• • Birthweight \< 2000 g