Effects of rTMS With Different Stimulation Spots in Patients With Disorders of Consciousness

Launched by ZHUJIANG HOSPITAL · Jul 25, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a treatment called repetitive transcranial magnetic stimulation (rTMS) on patients with disorders of consciousness. These disorders can range from being in a coma to having minimal awareness of the environment. The researchers want to find out how different stimulation locations in the brain might help improve the patients' awareness and responses. They plan to enroll 84 participants who have experienced brain injuries within the past year and have been diagnosed with a disorder of consciousness. To be eligible, participants must not have a history of certain psychiatric conditions or any medical devices in their bodies that could interfere with the treatment.

During the trial, participants will receive rTMS treatment twice a day for one week. This involves using magnetic pulses to stimulate specific areas of the brain, which may help improve their conditions. Researchers will measure how well the treatment works by observing changes in the patients' behaviors and brain activity before and after the treatment. This study aims to better understand how to effectively use rTMS for these patients and may provide valuable insights into improving care for individuals with disorders of consciousness.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. acquired brain injuries less than 1 year and more than 28 days in DOC;
• • 2. clinical diagnosis of DOC Disease;
• • 3. no medical history of neuropsychiatric diseases;
• • 4. no contraindications for rTMS or EEG, no sedatives in use or other drugs that might interfere with brain stimulation, such as Na+ or Ca2+ channel blockers or NMDA receptor antagonists;
• • 5. stable state of disease and vital signs;
• • 6. the integrity of the individualized stimulation target cortex are verified by MRI.
• Exclusion Criteria:
• • 1. patients in other non-invasive or invasive neuroregulation trials;
• • 2. motor evoked potential (MEP) in M1 region cannot be induced by TMS pulse;
• • 3. uncontrolled epilepsy, seizure within 4 weeks before enrollment;
• • 4. metallic implant in the skull, pacemaker, craniotomy under the stimulated site, implanted brain device.