Proteinopathies Expression in Skin of Neurodegenerative Disorders

Launched by UNIVERSIDAD AUTONOMA DE SAN LUIS POTOSÍ · Jul 29, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how certain proteins behave in the skin of people with neurodegenerative diseases like Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS). Researchers want to see if there are unique patterns of these proteins in the skin of patients compared to healthy individuals. By examining skin samples, the study aims to learn more about the differences in protein patterns, which could help improve understanding and diagnosis of these conditions.

To participate, you need to be 45 years or older and have a diagnosis of one of the targeted neurodegenerative diseases. Healthy individuals who want to help can also join, as long as they don’t have a family history of these diseases or any signs of dementia. Participants will provide a small skin biopsy, which will be analyzed in the lab. It's important to note that certain health conditions may exclude you from participating, such as a history of serious brain issues or skin diseases. If you choose to join, you’ll be contributing to important research that could lead to better insights into these challenging conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria for patients:
• • Patients 45 years and older
• • Men and women
• • Patients diagnosed with Alzheimer's disease, frontotemporal lobe dementia, Parkinson's disease, atypical Parkinsonism, amyotrophic lateral sclerosis or normal pressure hydrocephalus
• • Patients that voluntarily accept to participate in the study and accept the consent form
• Inclusion Criteria healthy control subjects:
• • People 45 years and older
• • Men and women
• • Subjects can be related to a patient but not by blood (for example spouse of a patient)
• • Subjects don't have direct family history of a neurodegenerative control
• • Subjects don't have any clinical findings suggesting dementia
• • Subjects voluntarily accept to participate in the study and accept the consent form
• Exclusion Criteria:
• • Patients or controls that have a personal history of cerebrovascular disease, psychiatric disease, post traumatic dementia or HIV related dementia
• • Patients in which the diagnosis is not clear or hasn't been confirmed
• • Patients or controls that have a neuroinfection
• • Patients or controls that a diagnosed skin disease
• • Patients that have an "atypical" presentation of the disease
• • Patients or controls that have diagnosis of a coagulopathy