Racecadotril Versus Standard Treatment in Decreasing the Duration of Acute Diarrhoea in Children

Launched by LIAQUAT NATIONAL HOSPITAL & MEDICAL COLLEGE · Jul 30, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a medication called racecadotril, compared to standard treatments, to see if it can help reduce the duration of acute watery diarrhea in children. Acute watery diarrhea is when a child has three or more loose stools a day for at least three days. The trial will look at how many stools children pass in the first 48 hours after starting treatment and how long they need to stay in the hospital. The goal is to find out if adding racecadotril to regular treatment will help children get better faster.

To be eligible for the trial, children must be between 3 months and 5 years old and have been hospitalized with acute watery diarrhea within the first 24 hours of having symptoms. However, children with certain conditions, like chronic diarrhea or severe dehydration, will not be included in the study. If a child participates, they can expect to receive either the new medication or standard treatment while the researchers carefully monitor their progress. This trial is not yet recruiting participants, but it aims to gather important information that could help treat children with this common condition more effectively in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Hospitalized Patients with acute watery diarrhea of both genders who are
• • 1. Age: 03 months to 05 years
• • 2. Present in first 24 hours of onset of disease.
• Exclusion Criteria:
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• • 1. Parenteral Diarrhea
• • 2. Chronic Diarrhea like Coeliac disease, Lactose intolerance
• • 3. Mal-absorption Syndromes
• • 4. Diarrhea related to food poisoning, dysentery as suggested by history
• • 5. Severe dehydration patents who are vitally unstable.
• • 6. Diarrhea associated with measles.
• • 7. Persistent vomiting
• • 8. Abdominal distention
• • 9. Patients allergic to racecadotril
• • 10. Patients managed before enrolled to study