Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling

Launched by UNIVERSITY HEALTH NETWORK, TORONTO · Jul 26, 2024

Keywords

ClinConnect Summary

This clinical trial is looking to improve how doctors predict the progression of various neurodegenerative diseases, which can cause dementia, including Alzheimer's disease, Lewy body dementia, vascular dementia, and others. Researchers aim to develop a model using blood tests and other information to better understand how these diseases progress over time. This study is currently recruiting participants aged 40 to 95 who have been diagnosed with mild cognitive impairment (MCI) or early dementia. It's important that participants have a study partner who can help provide information about their condition, as some assessments will require input from someone who knows them well.

If you or a loved one qualifies for this study, you can expect to take part in assessments that help researchers gather valuable information about your condition. The trial will be conducted under the supervision of trained professionals who will ensure that participants are able to complete the necessary procedures. This study aims to create a clearer picture of how different neurodegenerative diseases affect individuals, which could lead to better care and support for patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Referring diagnosis of MCI or early dementia
• • Age 40-95
• • Study partner who has some weekly contact with patient. Some of the neuropsychological assessment require collateral from close contacts to assess cognition and functioning. Since neurodegenerative diseases can be associated with reduced cognition, including reduced awareness of one's own impairments, participants will be assessed for their capacity to consent at all study visits.
• • Must, in the opinion of the site investigator, be able to complete most study procedures.
• Exclusion Criteria:
• • Participants who are not able to complete the majority of assessments in the opinion of the PI are excluded from the study. Exclusion criteria are evaluated at the site investigator's discretion; if the site investigator believes that the participant's symptoms are due to causes other than neurodegeneration, despite the presence of an exclusionary condition, the investigator may overrule the exclusion.