Simplified Papilla Preservation Flap(SPPF) and Enamel Matrix Derivative(EMD) With or Without Connective Tissue(CTG) Wall for the Treatment of Non Contained Infrabony Defects. A Randomized Controlled Clinical Trail

Launched by KRISHNADEVARAYA COLLEGE OF DENTAL SCIENCES & HOSPITAL · Jul 27, 2024

Keywords

ClinConnect Summary

This clinical trial is looking into a new treatment approach for people with certain types of periodontal (gum) disease that cause deep bone defects in the jaw, known as non-contained infrabony defects. The researchers want to see how effective a treatment that combines an enamel matrix derivative (a substance that helps in healing and bone regeneration) works when used with or without a connective tissue graft (a piece of tissue taken from another part of the body to help support healing). The goal is to find out which method leads to better healing and improvement of these bone defects.

To be eligible for this study, participants need to be between 18 and 55 years old and have at least one significant bone defect in their gums, with specific measurements of pocket depth and bone loss. They also need to be in relatively good dental health, meaning they shouldn't have extensive gum disease or a history of gum surgery in the affected area. If you join this study, you can expect to undergo a surgical procedure using the assigned treatment, and you'll be monitored for your healing progress afterward. This trial is not yet recruiting, so if you're interested, keep an eye out for updates!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients willing to participate in the study.
• • Participants aged ≥18 years to 55 years.
• • Presented with non contained infra bony defects.
• • Presence of at least 1 non contained infra bony defect(IBD) with a pocket probing depth ≥6mm after reevaluation of the hygienic phase and a depth of IBD ≥3mm as detected on radiographs, with radiographic angulation of ≥37⸰ , and exhibiting a 1 or 2 wall infra bony defect15(assessed by a bone sounding and confirmed intrasurgically)
• • Patient's full mouth plaque score and bleeding score \<20% at the time of surgical procedure.
• • No history of periodontal surgery at the experimental site.
• Exclusion Criteria:
• • Grade III mobility, endodontically treated teeth.
• • Pregnant and lactating females.
• • History of tobacco smoking .
• • Patients with systemic disease.
• • Known allergy or hypersensitivity to EMD.
• • Presence of pulpal and peri apical involvement