Effect of Esketamine on Anxiety State in Patients Undergoing Abdominal Tumor Surgery

Launched by ZHEJIANG CANCER HOSPITAL · Jul 29, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at whether a medication called esketamine can help reduce anxiety in patients who are having surgery for abdominal tumors. Anxiety is a common experience for many people before surgery, and the goal of this study is to see if esketamine can make patients feel calmer during this time.

To participate in this study, you need to be between the ages of 18 and 70 and scheduled for abdominal tumor surgery. You should also have a certain level of anxiety, as measured by a specific anxiety scale. However, there are some people who cannot join, such as those with serious mental health issues or certain severe health conditions. If you decide to join, you will receive esketamine before your surgery, and the researchers will monitor how it affects your anxiety levels. This study is currently recruiting participants, so if you’re interested, it’s a good time to talk to your healthcare provider about it.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients undergoing abdominal tumor surgery;
• • older than 18 years old and younger than 70 years old;
• • ASA grade I-III；
• • Hamilton anxiety scale ≥ 8.
• Exclusion Criteria:
• • Having serious mental illness before surgery or on antipsychotic medication in the two weeks before screening;
• • Severe organ function lesions such as heart failure (left ventricular ejection fraction \<30%), myocardial infarction, kidney failure (requiring kidney replacement therapy), liver function impairment (Child-Pugh grade C), etc.
• • Patients arranged to receive general anesthesia combined with epidural anesthesia patients;
• • Patients who cannot communicate, read or write due to visual, auditory, language or other reasons;
• • Patients allergic to ketamine;
• • Patients refused to use postoperative self-controlled intravenous analgesia pump;
• • Patients refused to participate in the study.