Comparison of Efficacy and Safety Between Ciprofol and Remimazolam During Fiberoptic Bronchoscopy

Launched by ANHUI PROVINCIAL HOSPITAL · Jul 30, 2024

Keywords

ClinConnect Summary

This clinical trial is designed to compare two medications, ciprofol and remimazolam, to see which one works better and is safer for patients undergoing a procedure called fiberoptic bronchoscopy. This procedure uses a thin tube with a camera to look inside the lungs, and it’s often done with the help of anesthesia to keep patients comfortable. While both ciprofol and remimazolam are being explored as alternatives to a commonly used anesthesia called propofol, this study aims to find out which of the two might be more effective and safer.

To participate in this trial, you need to be at least 18 years old and scheduled for a bronchoscopy with a specific type of breathing mask. You should also be in good health overall, with certain physical status as defined by a medical organization. However, if you have serious health issues, allergies to certain medications, or if you’re pregnant or breastfeeding, you may not be eligible. If you join the study, you’ll receive one of the two medications during your procedure, and the research team will monitor you closely to ensure your safety and comfort. This study is not yet recruiting participants but will provide valuable information to help improve care for patients undergoing bronchoscopy in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. male or female patients with age ≥ 18 years old;
• • 2. scheduled to undergo bronchoscopy under laryngeal mask airway;
• • 3. with American Society of Anesthesiologists (ASA) physical status classes II to Ⅲ; and
• • 4. volunteering to participate in this study and signing an informed consent form.
• Exclusion Criteria:
• • 1. with contraindications to deep sedation/general anesthesia or with a history of sedation/anesthesia accidents;
• • 2. allergic to eggs, bean products, or experimental drugs (ciprofol, sufentanil, or remimazolam);
• • 3. difficult airway;
• • 4. with bradycardia or other serious cardiovascular diseases;
• • 5. with severe damages or diseases in important organs such as the lungs, brain, liver, or kidneys;
• • 6. using sedatives or antidepressants for a long time;
• • 7. pregnant or lactating women; and (8) unable to communicate or cooperate.