Gut Microbiota in Chronic GI Diseases

Launched by MCMASTER UNIVERSITY · Jul 29, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the gut bacteria, known as microbiota, in patients with various gastrointestinal (GI) conditions like Irritable Bowel Syndrome (IBS), inflammatory bowel disease (IBD), severe constipation, and celiac disease. The researchers want to understand how these gut bacteria differ between people who have these conditions and those who do not. To do this, they will take stool samples from participants and introduce them into germ-free mice to see how the mice's symptoms and gut bacteria change, along with any effects on their brains.

To participate in this study, individuals should have a diagnosed GI condition such as IBS, IBD, or active celiac disease, or be a first-degree family member of someone with celiac disease. Participants must be willing to sign consent forms and should not have taken antibiotics or probiotics in the last month. If you join the trial, you can expect to contribute to important research that may lead to better understanding and treatment of these GI disorders. The study is currently looking for participants aged between 6 and 93 years old, and they welcome individuals of all genders.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of IBD, active celiac disease (aTTG positive + endoscopic view and histological findings compatible), IBS (Rome IV criteria or physician diagnosis) severe motility disorders (severe constipation, severe functional dyspepsia) gluten sensitivity (IBS diarrhea predominant with positive anti gliadin antibodies and negative aTTG), functional diarrhea (Rome IV criteria), anal fissure and/or fistula or non-disease control individual or 1st degree family member of celiac patient.
• • Willingness to participate
• • Signed Informed Consent
• Exclusion Criteria:
• • Antibiotics in the last month
• • Probiotics in the previous month