Antimicrobial Efficacy of Nano-Based ICM on E.F

Launched by TANTA UNIVERSITY · Jul 30, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at new treatments for a type of infection called Enterococcus faecalis, which can occur in teeth that have had root canal procedures. Researchers want to see how effective two different types of special medications, made from tiny particles (called nanoparticles), are at reducing this infection in teeth that are showing signs of problems after treatment. The study is currently recruiting participants, and they are looking for individuals aged 18 to 80 who have specific kinds of single-rooted teeth that need further treatment due to symptoms like pain or swelling.

Eligible participants will have their infected teeth treated with these new medications and will be monitored throughout the process. It's important to note that some people, such as those with certain health conditions, pregnant or breastfeeding individuals, or those with teeth that have significant damage, cannot participate in this trial. This study could provide valuable information on how to better manage infections after root canal treatments, potentially leading to improved dental care for many patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Single rooted, single canal premolar teeth.
• • Teeth indicated for non-surgical root canal retreatment.
• • Teeth have signs and/or symptoms of post-treatment disease manifested by recurrent acute and/or chronic periapical abscess.
• • Teeth have clinical signs and symptoms of endodontic failure as sensitivity to percussion, pain, swelling or fistula.
• • Teeth with radiographic features of endodontic failure as persistent periapical lesion or widening of periodontal ligament.
• • Symptomatic or asymptomatic teeth with short root canal filling indicated for prosthetic restoration
• Exclusion Criteria:
• • Patients with any systemic diseases.
• • Pregnant or lactating patients.
• • Immunocompromised patients.
• • Non-restorable tooth.
• • Calcified root canal.
• • Teeth with root fracture.
• • Teeth with periodontal pocket deeper than 4mm.
• • Teeth have procedural error like ledge, broken instrument, or perforation