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Search / Trial NCT06533904

Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib Fractures

Launched by LOMA LINDA UNIVERSITY · Jul 30, 2024

Trial Information

Current as of July 22, 2025

Not yet recruiting

Keywords

Trauma Respiratory Failure Respiratory Distress Respiratory Insufficiency Rib Fractures Chest Wall Trauma Percutaneous Cryoablation Multimodal Pain Therapy Multimodal Pain Regimen

ClinConnect Summary

This clinical trial is studying a new treatment called percutaneous cryoablation to help manage pain and improve recovery for patients with multiple rib fractures. The researchers want to find out if this procedure not only reduces pain in the short and long term but also helps patients breathe better and enhances their overall quality of life. Participants will be compared to those receiving standard pain management to see how effective cryoablation is in improving their recovery.

To be eligible for the study, participants need to be over 18 years old, have more than two rib fractures, and have a pain score higher than 5 on a scale of 0 to 10. They should also have difficulty with breathing, as measured by a test called incentive spirometry. If eligible, participants will undergo the cryoablation procedure and will be monitored at different times afterward to assess their recovery. This trial is an important step in understanding how to better treat patients suffering from rib fractures and related complications.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • \> 18 years old
  • \> 2 rib fractures
  • Verbal Pain score \> 5
  • Incentive Spirometry \< 60% of predicted
  • Exclusion Criteria:
  • Isolated Fractures of Ribs 1-3 and/or 10-12
  • Posterior Rib Fracture \< 4 cm from costovertebral joint
  • Sternal, Clavicle, Scapula Fracture
  • Thoracic Spinal Fracture of any type
  • Open Abdominothoracic Surgery
  • Unstable Spine
  • Extensive Subcutaneous Emphysema
  • BMI \> 35
  • Plan for Rib Plating
  • Chronic Opioid Use
  • Prior to study enrollment: Intubated, Traumatic Brain Injury, Dementia, Cognitive Impairment, Encephalopathy
  • Coagulopathy, Shock at time of ablation
  • Inability to participate in activities of daily living prior to injury
  • Home O2 use prior to trauma
  • Inhalation Injury
  • Rib Fractures due to cardiopulmonary resuscitation
  • Life Expectancy \< 6 months
  • \> 48 hours from injury
  • Pregnant, Incarcerated

About Loma Linda University

Loma Linda University is a prominent academic institution dedicated to advancing health and wellness through innovative research and education. As a sponsor of clinical trials, Loma Linda University leverages its extensive medical and scientific expertise to conduct rigorous studies aimed at improving patient outcomes and public health. With a commitment to ethical practices and patient safety, the university collaborates with a diverse network of healthcare professionals and researchers to explore novel therapeutic interventions and enhance clinical knowledge across various medical disciplines. Through its clinical trials, Loma Linda University seeks to contribute valuable insights to the medical community and foster advancements in healthcare delivery.

Locations

Loma Linda, California, United States

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported