Sequential Method Determination of Oxycodone for Thoracoscope Surgery Median Effective Dose of Acute Pain Treatment

Launched by JIANBO WU · Aug 1, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how much oxycodone is needed to effectively manage pain after a specific type of surgery called thoracoscopic lobectomy, which is performed through small incisions in the chest. The researchers want to find the right dose of oxycodone for different age groups: one for patients under 65 and another for those 65 and older. By adjusting the dose based on how well the previous patient responded to the medication, the study aims to determine the best dose that helps manage pain effectively.

To participate in this trial, individuals need to be between 18 and 80 years old and must be undergoing their first thoracoscopic lobectomy under general anesthesia. They should also be in good overall health (classified as ASA physical status I to III) and able to give informed consent. However, those with certain health issues, like severe obesity or a history of chronic pain, will not be eligible. Participants can expect to receive personalized dosing of oxycodone based on their pain response during the study, helping improve pain management for future patients undergoing this type of surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. The first unilateral thoracoscopic lobectomy was performed under general anesthesia
• • 2. age 18- 80 years old
• • 3. American Society of Anesthesiologists (ASA) physical status I-III
• • 4. Sign the informed consent of the patients
• Exclusion Criteria:
• • 1. Moderate to severe obesity (i.e., BMI \> 30kg/m2)
• • 2. Allergic or hypersensitive reaction to oxycodon
• • 3. A history of chronic pain
• • 4. Patients with significant heart, pulmonary, liver or renal disease