Hematopoiesis in MBL and CLL Versus Healthy Age-Matched Control Subjects

Launched by MAYO CLINIC · Jul 31, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how the bone marrow of patients with Chronic Lymphocytic Leukemia (CLL) and Monoclonal B-Cell Lymphocytosis (MBL) responds to infections compared to healthy individuals of similar ages. The goal is to understand how these conditions affect the body’s ability to produce blood cells, which are crucial for fighting off infections.

To participate in this study, you need to have a confirmed diagnosis of CLL or MBL. This includes individuals who have not yet started treatment, those currently undergoing treatment, and those who have received treatment in the past. Healthy individuals who do not have CLL or MBL can also join the study as control participants. Unfortunately, if you are under 40 years old, you will not be eligible to participate. Those who join the trial can expect to undergo assessments that will help researchers learn more about the differences in bone marrow function between the groups. This research could provide valuable insights into how to better manage and treat these blood disorders.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Subjects in the CLL cohort who are eligible for these studies will have a clinically established diagnosis of CLL as assessed by flow cytometry and will include subjects who
• • Remain untreated
• • Are currently being treated
• • Who have already been treated
• • Subjects in the MBL cohort will have a clinically established diagnosis of MBL
• • Healthy age-matched control subjects
• • Healthy younger control subjects aged \> 40 years
• Exclusion Criteria:
• • Anyone under 40
• • Healthy control subjects must not have a diagnosis of CLL or MBL