Synergy of Elevation of the Head and Thorax and REBOA During Out-of-Hospital Cardiac Arrest

Launched by UNIVERSITY HOSPITAL, GRENOBLE · Jul 31, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a new approach to treating out-of-hospital cardiac arrest (OHCA), which is when a person's heart suddenly stops beating outside of a hospital. Researchers want to see if combining two techniques—automated head and chest elevation during CPR (AHUP-CPR) and a method called Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)—can improve blood flow to the heart and brain and ultimately lead to better survival rates and neurological outcomes. Previous studies indicate that using these techniques together may help deliver more blood to critical areas during CPR.

To participate in this trial, individuals must be at least 18 years old and have experienced a witnessed cardiac arrest with a short no-flow duration of under 10 minutes. They should also have certain measurements indicating CPR quality when the medical team arrives. Participants will be recruited from the Grenoble Metropolitan area and must be enrolled in French social security. It's important to note that individuals who regain a heartbeat before the REBOA procedure or have certain medical conditions may not be eligible. Overall, participants can expect to receive a combination of these advanced CPR techniques to see if they can improve their chances of recovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient with age over or equal to 18 years old
• • Patient with a witnessed medical cardiac arrest and with a no-flow duration under 10 min
• • Patient with EtCO2 greater than 20 mmHg at REBOA team arrival
• • Patient located in the Grenoble Metropolitan area
• • Patient affiliated to French social security
• Exclusion Criteria:
• • Patient with ROSC before REBOA placement.
• • Patient eligible to extracorporeal life support (according to local guidelines).
• • CA of traumatic origin (including drowning or hanging).
• • Patients whose size is not adapted to the LUCAS device: height of the sternum from 170 to 303 mm or maximum chest width of 449 mm. The use of the LUCAS device is not subject to a patient weight condition.
• • Cardiac arrest for which resuscitation seems unjustified (inevitable death, terminally ill irreversible condition, too long duration of cardiac arrest, advance personal directives of no-resuscitation).
• • Obvious pregnancy at inclusion.
• • Subject in a period of exclusion from another clinical investigation.
• • Patients with a femoral arterial access site that cannot accommodate an 8 Fr (minimum) introduces sheath