Hypofractionated External Beam Radiotherapy With Adaptive Planning for Endometrial and Cervical Cancers

Launched by JONSSON COMPREHENSIVE CANCER CENTER · Aug 1, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a type of radiation therapy called hypofractionated external beam radiotherapy for women who have had surgery to remove endometrial or cervical cancer. Instead of receiving many small doses of radiation over several weeks, participants will receive fewer but larger doses in just five sessions. The goal is to see if this approach makes the treatment easier to tolerate while still controlling side effects.

To be eligible for this study, participants must be women aged 18 or older with confirmed endometrial or cervical cancer who have already undergone surgery to remove their tumors. They should not be receiving other treatments like chemotherapy at the same time. If you join the trial, you can expect to have five treatment sessions that last about an hour each, scheduled on weekdays. After the treatments, there will be follow-up appointments to monitor your health and answer any questions for up to five years. This study is currently recruiting participants, so it’s a great opportunity for those who meet the criteria.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Histologically confirmed endometrial or cervical cancer
• • Surgical resection of the primary tumor
• • International Federation of Gynecology and Obstetrics (FIGO) Stage IA-IVB endometrial cancer OR FIGO Stage IA-IIA cervical cancer that meets indications for receiving adjuvant pelvic radiotherapy alone as standard of care
• • Age ≥ 18 years old
• • Karnofsky performance status (KPS) ≥ 60 or Eastern Cooperative Oncology Group (ECOG) 0-2
• Exclusion Criteria:
• • Must not meet indications for receiving concurrent chemotherapy as standard of care
• • Active treatment of a separate malignancy
• • History of prior irradiation to the area to be treated