Prediction Augmented Screening Initiative

Launched by VA OFFICE OF RESEARCH AND DEVELOPMENT · Aug 2, 2024

Keywords

ClinConnect Summary

The Prediction Augmented Screening Initiative is a clinical trial focused on improving lung cancer screening for Veterans. Lung cancer is a major health issue, causing more deaths than many other cancers, and it’s often found too late for successful treatment. This trial aims to find ways to identify which Veterans are most likely to benefit from lung cancer screening, encouraging more people to get checked early when treatment is more effective. The goal is to make screening more efficient and accessible, particularly for Black Veterans, who are at higher risk but less likely to be screened.

To be eligible for this trial, participants must be Veterans who have a primary care provider at one of the participating sites and meet specific criteria, such as being between 50-80 years old and having a history of smoking. Participants can expect to engage in shared decision-making conversations about their lung cancer screening options, tailored to their individual risk factors. This study is not yet recruiting, but it represents a significant effort to enhance lung cancer screening and improve health outcomes for Veterans.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Veterans assigned a PCP at a participating site and who meet inclusion criteria at any point during the study timeframe will be enrolled into the trial. There will be two paths to patient inclusion:
• • meeting USPSTF eligibility criteria for LCS, as currently encoded in the background logic of LCS clinical reminders maintained by the VA National Center for Lung Cancer Screening (i.e., age 50-80 years; smoked 20 pack-years; current smoking or quit \<15 years ago) OR
• • predicted benefit calculated using LYFS-CTVA model exceeds a stringent high-benefit threshold of life-year gains with annual LCS, as recommended in the 2021 CHEST LCS guidelines
• Exclusion Criteria:
• • Veterans who have previously undergone lung cancer screening, are diagnosed with lung cancer, or who do not meet eligibility criteria outlined above