Impact of High Versus Lower Oxygen Fraction Prior to Extubation on Postoperative Pulmonary Atelectasis Measured With EIT

Launched by BETH ISRAEL DEACONESS MEDICAL CENTER · Jul 31, 2024

Keywords

ClinConnect Summary

This clinical trial is studying whether using a lower concentration of oxygen (70%) before removing the breathing tube after surgery can help reduce a condition called atelectasis, which is the collapse of lung tissue. Normally, patients are given 100% oxygen at this stage, but researchers want to see if this might actually increase the risk of atelectasis. By comparing the effects of these two oxygen levels in patients undergoing general anesthesia, the trial aims to find out if lower oxygen can help keep the lungs healthier after surgery.

To be eligible for this study, participants need to be at least 18 years old and scheduled for elective surgery requiring general anesthesia and a breathing tube, with the surgery expected to last between 1 to 5 hours. Patients who cannot provide consent, have severe health issues, or certain medical conditions like morbid obesity or heart disease may not qualify. Those who participate will have their oxygen levels, heart rate, and blood pressure monitored, and the study will check for lung problems using a special imaging technique. This trial is currently looking for volunteers, so if you or someone you know fits the criteria and is interested, it could be a chance to contribute to important research in postoperative care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years
• • Elective surgery with general anesthesia and endotracheal intubation
• • Expected duration of surgery 1-5 hours
• • Consent obtained from patient
• Exclusion Criteria:
• • Patients with inability to give written informed consent
• • American Society of Anesthesiologists (ASA) physical status\> IV
• • Morbid obesity BMI \> 40
• • Suspected pregnancy and lactation
• • Cardiac or thoracic surgery
• • Patients with thoracic epidural catheters
• • Patients with active implantable devices, such as pacemakers, cardioverter defibrillators, or neurostimulators
• • Compromised airways
• • Impaired oxygenation at baseline or during surgery