Immune Registry for BK in Kidney Transplant Recipients

Launched by VIRGINIA COMMONWEALTH UNIVERSITY · Jul 31, 2024

Keywords

ClinConnect Summary

This clinical trial, called the Immune Registry for BK in Kidney Transplant Recipients, is studying the effects of a virus known as BK virus on patients who have received a kidney transplant. After a kidney transplant, some patients can develop BK virus infections, which can lead to serious complications, such as kidney injury and an increased risk of the body rejecting the new kidney. The study aims to better understand how this virus affects patients and how to balance the treatment of the virus with the risk of rejection of the transplanted kidney.

To participate in this trial, you must be an adult (over 18 years old) who has received a kidney transplant from a deceased donor and has recently been diagnosed with BK viremia (the presence of the virus in the blood). Unfortunately, if you are pregnant or have received a multi-organ transplant, you will not be eligible to join the study. Participants will be monitored closely to gather important information about how to treat BK virus infections effectively while protecting the transplanted kidney. The trial is currently recruiting participants, and everyone involved will contribute to valuable research that can improve outcomes for future kidney transplant recipients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult (\>18 years old) male and female, deceased donor KT recipients
• • Will include single organ transplants.
• • Each participant must also have recently been diagnosed with BK viremia.
• • In addition to the aforementioned inclusion criteria, each participant in the sub-study must also have recently been diagnosed with BK viremia or have difficult-to-treat BKV \> 3 logs (BKV log does not decrease by more than 1 log copy/ml drop on second per protocol lab).
• Exclusion Criteria:
• • Prisoners will not be included in the study
• • Multi-organ transplants and pregnant women