Angiotensin II Stress Test. Renin Kinetics During Treatment of Vasoplegic Shock With Angiotensin II.

Launched by UNIVERSITY MEDICAL CENTRE MARIBOR · Aug 1, 2024

Keywords

ClinConnect Summary

This clinical trial, called the Angiotensin II Stress Test, is studying how a medication called angiotensin II can help patients with a serious condition known as vasoplegic shock. In this type of shock, patients often have very low blood pressure, which can lead to dangerous complications. The trial aims to understand the relationship between a substance called renin, which is involved in blood pressure regulation, and the effectiveness of angiotensin II treatment. Researchers want to find out if measuring renin levels can help identify which patients are most likely to benefit from angiotensin II when other medications haven’t worked.

To be eligible for this trial, participants must be adults with distributive shock that has lasted less than 72 hours and have not responded to standard treatments with noradrenaline and vasopressin. They should also be expected to survive for more than 24 hours and have no serious health issues that would prevent them from participating. If you join the study, you can expect to receive close monitoring and care while researchers gather important information about how angiotensin II and renin levels relate to your treatment and recovery. This study is currently recruiting participants, and it could help improve treatment options for people experiencing this critical condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • patients with distributive shock lasting \< 72 hours
• • a goal mean arterial pressure (65-85 mmHg) not achieved despite an infusion of at least noradrenaline 0.3 mcg/kg/min and vasopressin 0.03 IE/min
• • the patient did not get angiotensin II before
• • predicted survival is \>24h
• • no limitations for active treatment
• Exclusion Criteria:
• • burns \>20% body area
• • acute coronary syndrome
• • bronchospasm
• • liver disease (MELD ≥30)
• • severe acute bleeding (need for 4 or more units of concentrated erythrocyte)
• • acute mesenteric ischemia
• • aortic dissection
• • leucopenia \<1000/mm3
• • pregnancy
• • Raynaud disease, systemic sclerosis, vasospastic disease
• • the need for daily dose of hydrocortisone 500 mg or more
• • ECMO