Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy

Launched by MEDICAL UNIVERSITY OF SOUTH CAROLINA · Aug 1, 2024

Keywords

ClinConnect Summary

Chronic lower back pain (LBP) and lumbosacral radiculopathy are common, disabling, and costly conditions. The lifetime prevalence of LBP is estimated to be greater than 70% in industrialized countries, with a 1-year prevalence of 15-45% and LBP is the most common cause of years lived with disability worldwide. Chronic LBP (defined as LBP lasting less than 3 months) is a complex and heterogeneous condition with nociceptive and neuropathic components.

The goals of treatment of chronic LBP and lumbosacral radiculopathy are to reduce pain, maintain function, and prevent future exacerbation. Gu...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Older than 18 years of age
• • Willing and have capacity to provide informed consent
• • History of symptoms for longer than three months (so as to minimize the chance of spontaneous recovery)
• • Pain-DETECT questionnaire (PD-Q) indicating neuropathic component of pain
• Exclusion Criteria:
• • Self-reported or medical records showing history of lumbar spine, hip, or lower extremity surgeries within three months
• • Chronic opioid use (determined by self-report and review of Prescription Drug Monitoring Program database) - defined as more than 15 morphine milligram equivalents (MME) per day for at least 2 weeks
• • Self-reported or medical records showing history of painful peripheral neuropathies (from diabetes mellitus, HIV, or induced by chemotherapy)
• • Self-reported allergies to study medications
• • Pregnant women (determined by self-report) and prisoners