Clinical Study on the Effect of CPAP on AF Recurrence After Catheter Ablation in Patients with AF and OSA

Launched by SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY · Aug 4, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how using Continuous Positive Airway Pressure (CPAP) therapy can affect the return of atrial fibrillation (AF) in patients who have both AF and moderate to severe obstructive sleep apnea (OSA) after they undergo a procedure called catheter ablation. Atrial fibrillation is a heart condition that can lead to serious complications like stroke and heart failure, and OSA is a sleep disorder that causes breathing problems during sleep. The researchers want to find out if treating OSA with CPAP can help reduce the chances of AF coming back after the ablation procedure.

To participate in this trial, individuals must be at least 18 years old and have been diagnosed with AF and moderate to severe OSA, which is determined by specific tests. Participants will need to agree to use CPAP at home for a certain amount of time each week. The trial is currently recruiting participants, and those who join can expect to undergo assessments and receive guidance on their treatment. It’s important to note that some individuals may not be eligible due to certain health conditions or recent medical history. The goal of the study is to provide better treatment recommendations for patients experiencing both AF and OSA.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Clinical diagnosis of AF combined with moderate to severe OSA (OSA diagnostic criteria: apnea hypopnea index (AHI) greater than 15/hour, and at least 80% of all events are respiratory sleep obstructive events; AF includes persistent atrial fibrillation and paroxysmal atrial fibrillation)
• • 2. Age ≥ 18 years old
• • 3. The patient voluntarily participates in the project and signs informed consent
• • 4. All patients undergo overnight sleep pressure titration at the sleep center to determine the minimum pressure value for continuous positive airway pressure ventilation at home. All patients are required to undergo CPAP treatment at home at least 5 days a week, with each session lasting at least 4 hours
• Exclusion Criteria:
• • 1. Patients with neuromuscular disorders, pulmonary hypopnea, and severe lung diseases
• • 2. Preoperative confirmation of thrombus in the left atrium
• • 3. The patient has no desire for conversion
• • 4. Secondary atrial fibrillation (hyperthyroidism, tumors, etc.)
• • 5. Individuals with contraindications to anticoagulants
• • 6. Left atrial diameter (LAD) exceeding 60mm (2D echocardiography long axis section data)
• • 7. Pregnant women
• • 8. History of myocardial infarction, percutaneous coronary intervention, and cardiac surgery in the past three months
• • 9. Stroke or transient ischemic attack in the past six months
• • 10. After artificial valve implantation surgery
• • 11. Severe renal insufficiency (creatinine Cr\>2.5mg/dl or\>221umol/L, or glomerular filtration rate eGFR\<30ml/min/1.73m2)
• • 12. Acute diseases or active infections that occur before surgery, recorded as pain, fever, positive blood culture, and/or leukocytosis, or have been treated with antibiotics.
• • 13. Expected survival period\<1 year