Intraoperative Parathyroid Hormone Monitoring to Guide Surgery in Renal hyperparathyroIdism

Launched by MCMASTER UNIVERSITY · Aug 4, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at a method called intraoperative parathyroid hormone monitoring (IOPTH) to see if it can help guide surgery for patients with certain types of hyperparathyroidism, which is a condition where the body produces too much parathyroid hormone. The main goal is to find out if a larger study can be done to test how effective this monitoring method is compared to standard surgery without it. Participants will be randomly assigned to either have surgery guided by one of four IOPTH criteria or to a control group that does not use this monitoring.

To be eligible for this trial, participants need to be 18 years or older and must be a candidate for specific types of parathyroid surgery. They should have secondary or tertiary hyperparathyroidism, often related to chronic kidney disease. Throughout the study, participants will be asked to complete some questionnaires about their quality of life and cognitive abilities, and they will also have blood tests. It's important to note that this study is not yet recruiting participants, but it aims to gather valuable information for future research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18 years of age or older
• • Candidate for subtotal parathyroidectomy or total thyroidectomy with or without autotransplantation
• • Tertiary hyperparathyroidism and/or recurrent hyperparathyroidism OR secondary hyperparathyroidism diagnosed with any stage of chronic kidney disease
• Exclusion Criteria:
• • Undergoing parathyroidectomy for primary hyperparathyroidism
• • Pregnant or breastfeeding women
• • Undergoing revision parathyroidectomy
• • Undergoing minimally invasive or video-assisted parathyroidectomy
• • Unable to provide written consent to be participant in study
• • Unable to complete study follow-up visits