Studying Phenotypes of Gestational Diabetes Mellitus in an Asian Pregnant Cohort

Launched by NATIONAL UNIVERSITY HEALTH SYSTEM, SINGAPORE · Aug 5, 2024

Keywords

ClinConnect Summary

This clinical trial is studying gestational diabetes mellitus (GDM), a condition that some women develop during pregnancy when their bodies cannot properly manage blood sugar levels. GDM can lead to complications for both mothers and babies, such as preterm birth and an increased risk of developing diabetes later on. The research aims to better understand the different types of GDM, especially in Asian women who may be more affected due to factors like obesity and genetics. By using advanced technologies to monitor blood sugar and other health indicators, the study hopes to improve how GDM is treated and managed.

To participate in this study, women must be between 21 and 45 years old, have a single pregnancy, and be overweight or obese (with a body mass index, or BMI, of 23 or higher). They should also be within the first 13 weeks of pregnancy and plan to deliver their baby at the National University Hospital in Singapore. Participants will wear a device that continuously monitors their blood sugar for at least seven days at each clinic visit. The study will take place over three years and will involve around 800 women, helping to create better screening and treatment guidelines for managing GDM in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Gestational age of ≤ 13 weeks 6 days
• • Overweight and obese subjects with BMI of 23kg/m² - 24.9kg/m² and ≥ 25.0kg/m², respectively
• • Aged 21-45 years with singleton pregnancy
• • Plan to be followed up during the whole pregnancy and deliver at NUH
• • Chinese, Malay or Indian ethnicity for pregnant subject
• • Can complete questionnaires in English language
• • Willing to wear continuous glucose monitoring device at least for 7 days at each required clinic visit
• Exclusion Criteria:
• • Participants who are not Singapore citizens or Singapore Permanent Residents, not intending to eventually deliver in Singapore National University Hospital and to reside in Singapore for the next 2 years
• • Have serious skin conditions (eg. eczema) that precludes wearing the sensor for 14 days
• • With history of Type 1 diabetes or Type 2 diabetes
• • With chronic preexisting life-threatening conditions including pancreatic cancer, end-stage kidney dysfunction, and psychosis
• • Unable to read or speak English