Dietary Intervention on Atopy

Launched by NATIONAL UNIVERSITY OF SINGAPORE · Aug 7, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how changes in diet might affect people with atopic dermatitis, a skin condition that causes itchy and inflamed skin. The researchers want to understand if specific dietary habits can help manage or reduce the symptoms of this condition. The trial is currently looking for participants aged 21 to 65 who have mild to moderate atopic dermatitis, live in Singapore, and do not have any major health issues or food allergies.

If you join the study, you will need to follow specific dietary guidelines and refrain from using any moisturizers or skin creams during the trial. This means you should be ready to stick to the study's procedures and be available for the entire duration. It’s also important that you do not smoke or drink alcohol regularly, as these factors can affect the study results. Overall, this trial aims to gather valuable information that could help improve dietary recommendations for managing atopic dermatitis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Presence of current, mild-to-moderate atopic dermatitis/eczema at flexural areas
• • 2. 21 to 65 years of age (inclusive) at screening
• • 3. Must be English-literate and able to give informed consent in English
• • 4. Be residing in Singapore and will not be travelling outside of Singapore during the study period
• • 5. Reliable and willing to follow study procedures and be available for the duration of the study
• • 6. Non-smokers (tobacco and e-cigarette)
• • 7. Non-drinker (no regular or frequent consumption of alcohol)
• • 8. Overtly healthy with no pre-existing medical conditions (e.g., diabetes, hypertension, cancer, blood disorders, degenerative/liver/autoimmune/immune/renal diseases, or psychiatric conditions)
• • 9. No food allergies to test foods
• • 10. No needle phobia
• • 11. Be willing to not apply any moisturiser, cosmetics, and/or topical cream on the skin throughout the entire duration of the study.
• Exclusion Criteria:
• • 1. Concurrent participation in other research studies
• • 2. Pregnancy or lactating individuals
• • 3. Known or ongoing psychiatric disorders within 3 years
• • 4. Known severe nutritional deficiency
• • 5. Vegetarian/vegans (as meat will be included in the diet)
• • 6. Individuals who made a significant dietary change in the past 12 months
• • 7. Having a pre-existing dietary restriction that would interfere with the adherence to a whole diet meal
• • 8. Regular use of strong medication (western and/or traditional), therapies, and alternative medications
• • 9. Regular nutritional supplements in the past 12 months Regular consumption of oral contraceptive pills and/or steroid hormones
• • 10. Antibiotic use in the past 2 months
• • 11. Any long-term hospitalisation or surgery during the 6 months before enrolment in study
• • 12. Significant change in weight (+/- 5.0%) during the past month
• • 13. History of bleeding diathesis or coagulopathy (or any bleeding disorders)
• • 14. Having donated blood of more than 500 mL within 4 weeks of study enrolment