Establishing Daily Applicable Parameters for Using Magnetic Resonance Spectroscopy of Spinal Cord

Launched by M.D. ANDERSON CANCER CENTER · Aug 8, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a technique called Magnetic Resonance Spectroscopy (MRS) to see if it can effectively evaluate lesions (abnormal tissues) in the spinal cord. Researchers want to understand how well MRS can help in identifying changes in the spinal cord that may not be visible through other imaging methods. The trial is currently looking for participants, specifically adults over the age of 18 who do not have certain health issues like cancer, specific spinal diseases, or any history of spinal cord lesions.

To participate, individuals must be healthy or, if they are patients at high risk for a type of cancer that can affect the spinal cord, they should not show any signs of that disease in recent tests. Participants can expect to undergo some imaging tests while helping researchers learn more about how MRS can be used for spinal cord assessment. It’s important to note that this study is not for pregnant or breastfeeding individuals, those with a history of spinal surgery, or anyone with certain spinal conditions. If you think you might be eligible and are interested, you can talk to your doctor for more information.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Volunteers:
• • Adults \> 18 years
• • Healthy with no malignancy, demyelinating disease, back pain, degenerative disease, or spinal cord lesions.
• • Consent able patients.
• Patients with high risk for LMD to receive prophylactic CNS radiation:
• • Adults \> 18 years old.
• • MR or CSF without evidence of LMD.
• • Patients with high risk for LMD to receive CSI as part of standard treatment of prophylactic LMD disease.
• • Consent able patients, willingness and ability to comply with the study procedures.
• • No spinal cord lesions.
• Exclusion Criteria:
• Volunteers:
• • Age \< 18 years
• • Pregnant or breastfeeding individuals.
• • History of cancer.
• • History of spinal cord lesions including malignant, demyelinating, or inflammatory.
• • History of prior spinal surgery.
• • History of implantable devices.
• • History of MR claustrophobia.
• • Degenerative disease or spinal/back pain including myelopathy and radiculopathy.
• • Scoliosis.
• Patients with high risk for spinal LMD:
• • Age \< 18 years
• • History of spinal cord lesions including malignant, demyelinating, or inflammatory.
• • History of prior spinal surgery.
• • History of implantable devices.
• • History of MR claustrophobia.
• • Degenerative disease or spinal/back pain including myelopathy and radiculopathy.
• • Scoliosis.