Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation-2 (TELSTAR-2)

Launched by UNIVERSITY OF TWENTE · Aug 7, 2024

Keywords

ClinConnect Summary

The TELSTAR-2 trial is a study aimed at understanding how to treat a specific type of brain activity called electrographic status epilepticus (ESE) in patients who are in a coma after a cardiac arrest. The main goals of the trial are to see if treating ESE can improve the recovery outcomes for these patients and to evaluate how this treatment affects healthcare costs. In this study, some patients will receive standard care along with anti-seizure medication, while others will only receive standard care without the medication.

To be eligible for the trial, participants must be at least 18 years old, in a coma after a cardiac arrest, and have specific findings on their brain monitoring (EEG) that suggest they have ESE. The trial is not yet recruiting participants, but it will involve patients from the Netherlands and Belgium. If someone qualifies and joins the study, they will receive close monitoring and care to help determine the best approach to treating their condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Coma (Glasgow Coma Scale score ≤ 8) after out of hospital cardiac arrest and resuscitation
• • 2. Age ≥ 18 years
• • 3. Continuous EEG with at least eight electrodes started \< 24h after return of spontaneous circulation (ROSC)
• • 4. ESE or possible ESE according to the Salzburg and ACNS criteria
• • 5. Possibility to start treatment within three hours after detection of ESE
• Exclusion Criteria:
• • 1. Known history of another medical condition with limited life expectancy (\< six months)
• • 2. Any progressive brain illness, such as a brain tumor or neurodegenerative disease
• • 3. Pre-admission Glasgow Outcome Scale score of 3 or lower
• • 4. Reason other than the neurological condition to withdraw treatment
• • 5. EEG background activity prior to the emergence of ESE indicative of extensive irreversible anoxic brain injury
• • 6. Follow-up impossible due to logistic reasons, for example not living in the Netherlands or Belgium