Evaluation of Nasal Non Invasive Ventilation in Management of Neonates With Respiratory Distress Using Lung Ultrasound

Launched by ALEXANDRIA UNIVERSITY · Aug 10, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how different types of non-invasive breathing support can help premature babies (born before 37 weeks of pregnancy) who are having trouble breathing. The researchers want to see which method—using a special mask called nIPPV, a continuous air pressure device known as nCPAP, or a nasal high flow cannula (NHFC)—works best to support these babies as they recover. They will monitor how long the babies need this breathing help and look at various factors, like whether they need to be intubated (put on a ventilator), how long they stay in the hospital, and their overall lung health during the first week of life.

To participate, babies must be less than 37 weeks old, able to breathe on their own, and show signs of respiratory distress, like rapid breathing or grunting. Babies with serious heart or lung problems, or those who have already been intubated, will not be eligible. Families involved in the trial can expect close monitoring of their baby's health and progress, which may help improve understanding and treatment for breathing issues in premature infants.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria: Preterm \<37 wk. gestational age admitted to the NICU with spontaneous breathing and clinical manifestations of RD (tachypnea, nasal flaring, intercostal and subcostal retraction and or grunting).
• Exclusion Criteria:
• • 1. Obvious major congenital abnormalities.
• • 2. Any of the baby intubated for resuscitation or for other reasons.
• • 3. Neonates need invasive mechanical ventilation.
• • 4. Pulmonary hemorrhage.
• • 5. Severe cardiovascular instability.
• • 6. Cardiopulmonary arrest needing prolonged resuscitation.
• • 7. Birth asphyxia (one-minute Apgar score ≤ 3).
• • 8. Major cardiac diseases (not including patent ductus arteriosus).