The Effect of Pre-exercise Feeding on Bone Turnover Biomarkers

Launched by SHEFFIELD HALLAM UNIVERSITY · Aug 8, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how eating before exercise affects bone health, particularly in men with conditions like osteopenia or osteoporosis. The researchers want to find out if the timing of meals can enhance the benefits of aerobic exercise on bone metabolism. By understanding how food intake influences bone health in younger adults, the study aims to help create recommendations that could improve bone density and strength, potentially delaying the onset of osteoporosis-related fractures as people age.

To participate in this trial, you need to be a healthy Caucasian male aged around 28 years who is physically active, meeting certain exercise guidelines. Some people may not be eligible, such as current smokers, those with specific medical conditions affecting bone health, or anyone who has recently tested positive for COVID-19. If you qualify, you’ll be involved in exercises and feeding schedules that will help researchers gather important information on how to maximize bone benefits through diet and exercise. This study is not yet recruiting participants, but it represents an exciting opportunity to learn more about improving bone health.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Male (females excluded to remove the interplay between menstrual cycle and bone turnover)
• • Caucasian ethnicity
• • Aged 28 ± 4 years
• • Are physically active (meet the UK guidelines for physical activity of at least 150 minutes moderate intensity activity and/or at least 75 minutes of vigorous intensity activity per week)
• • Otherwise, healthy, able and willing to participate and provide written informed consent
• Exclusion Criteria:
• • Current smokers
• • Excessive alcohol consumption (max 15 alcohol units/week)
• • Any musculoskeletal injury/disabilities
• • Any conditions known to affect bone metabolism (e.g. uncontrolled hyper-/hypothyroidism, hyperparathyroidism, hypo-/hypercalcaemia) or malabsorption syndromes (e.g. Crohn's disease, coeliac disease or inflammatory bowel disease).
• • Taking any medication known to affect bone metabolism (such as glucocorticoids or bisphosphonates)
• • Positive Covid-19 test within the last 8 weeks
• • Suffered a fracture in the previous 12 months
• • Sedentary status (see physical activity inclusion criteria above)
• • Have been told by medical professionals that they should not take part in moderate to high intensity exercise
• • Should not be a professional athlete or take part in significant competitive recreational activity (takes no more than 4 structured exercise sessions per week on average)
• • History of diagnosed eating disorders