Peripheral Mononuclear Cells to Screen, Monitor and Stratify the Population at Risk of Osteoporosis and Fractures

Launched by ISTITUTO ORTOPEDICO RIZZOLI · Aug 9, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new way to diagnose and monitor osteoporosis, a condition that weakens bones and increases the risk of fractures. Researchers want to see if testing certain cells from the blood can help determine how severe a person's osteoporosis is, especially since standard bone density tests (DXA) often miss cases. By understanding how these blood cells behave, the goal is to create a better screening tool for osteoporosis that also considers differences between men and women.

To participate in this study, you need to be at least 40 years old, have a healthy weight, and either be healthy with regular check-ups, have osteopenia (a milder form of bone loss), or have osteoporosis (with or without fractures) and have had a DXA test. Unfortunately, some individuals may not be eligible if they have certain medical conditions like blood disorders, infections, or are pregnant. If you qualify and decide to join, you will be helping to improve osteoporosis diagnosis, which could lead to better care for many people at risk of fractures in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy patients (at risk and undergoing periodic follow-up and/or attending outpatient visits for preventive screening)
• • Osteopenic patients with an available DXA
• • Osteoporotic patients (fractured and non-fractured) with an available DXA or, for fractured patients, a DXA prescribed as part of clinical practice
• • Aged ≥ 40 years of both sexes
• • Body Mass Index (BMI) between 18.5 and 29.9
• Exclusion Criteria:
• • Hematopoietic system disorders (hemolytic, aplastic, and neoplastic anemias)
• • Coagulation disorders (hereditary or secondary to other disorders)
• • Infections (including HIV-HBV-HCV positivity)
• • Neoplastic diseases (primary and/or secondary tumors)
• • Pregnancy or breastfeeding
• • Alcohol consumption (\>20 g of alcohol per day currently or in the past)
• • Smoking (\>10 cigarettes per day, currently or in the past)
• • Diabetes
• • Treatment with therapeutic agents that may interfere with hematopoiesis (corticosteroids, immunosuppressive agents, cytotoxic drugs)