Influence of Preoperative Vitamin D Level on Postoperative Pain in Breast Cancer Surgery Patients

Launched by FAYOUM UNIVERSITY · Aug 9, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how vitamin D levels before surgery might affect pain after surgery in women undergoing treatment for breast cancer. Vitamin D is an important nutrient that helps with many aspects of health, and many breast cancer patients have low levels of it. The goal of this study is to see if having enough vitamin D before surgery can help reduce the amount of pain these patients experience afterward.

To participate in this trial, women aged 20 to 65 who are scheduled for a specific type of breast cancer surgery called a modified radical mastectomy may qualify. However, there are certain conditions that would exclude someone from joining, such as if they use strong pain medications regularly, have certain health issues that affect vitamin D levels, or have severe kidney or liver problems. Participants will have their vitamin D levels checked before surgery and will be monitored for pain afterward. This study aims to better understand the link between vitamin D and postoperative pain, which could help improve care for breast cancer patients in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion criteria:
• • Female patients ASA II -III.
• • aged 20-65 years, who will be scheduled to undergo elective unilateral breast cancer surgery.
• • modified radical mastectomy.
• Exclusion criteria:
• • Patient refusal.
• • Chronic opioid use.
• • cognitive disorders.
• • patients using drugs affecting the levels of calcium, phosphorus, and vitamin D, such as vitamin D supplement, calcitonin, and estrogen or its analogs, one month before enrolment.
• • hyperparathyroidism or undergoing parathyroidectomy.
• • diseases affecting vitamin D absorption, such as long-term diarrhea, chronic pancreatitis, biliary obstruction, colitis, partial resection of the small intestine.
• • severe liver and kidney diseases.
• • severe peripheral or central neuropathy.
• • heart failure.
• • pneumonia.
• • parenteral nutrition patients.