The Importance of Insulin Action in the Brain for the Immune System During Physical Activity

Launched by UNIVERSITY OF ULM · Aug 8, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how insulin works in the brain and its effects on the immune system during physical activity. Researchers want to understand how insulin delivery, given as a nasal spray, compares to a placebo (a spray with no active ingredients) on days when participants exercise on a bicycle. The goal is to see if insulin in the brain helps with immune responses during physical activity.

To be eligible for this trial, participants should be between 65 and 74 years old, have a body mass index (BMI) of less than 24, and not have any major health issues. They should also not smoke, abuse drugs or alcohol, or have low hemoglobin levels, which are important for overall health. If you decide to participate, you can expect to take part in exercise tests while receiving either the insulin spray or the placebo, helping researchers learn more about how insulin affects our body during exercise.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • BMI \< 24 kg/m2
• • no known primary diseases
• • hormonal contraception with a single-phase preparation
• Exclusion Criteria:
• • Alcohol or drug abuse
• • Smoking
• • At screening: Hb \< 12 g/dl for women and Hb \< 14 g/dl for men
• • Any (clinical) condition that would endanger participant's safety or question scientific success according to a physician's opinion.