Median Versus Ulnar Nerve Quantitative Electromyography Neuromuscular Blockade Monitoring Comparison

Launched by LOMA LINDA UNIVERSITY · Aug 10, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how well two different nerves in the arm—called the ulnar nerve and the median nerve—can be used to monitor muscle relaxation during surgery. Muscle relaxants are often used to help with surgeries, and it's important for doctors to know how deeply the muscles are relaxed and when they start to recover. The researchers want to compare the muscle responses from these two nerves to see if one is better than the other for monitoring muscle relaxation.

To be eligible for this study, participants need to be adults aged 18 to 75 who are scheduled for elective surgery that will last at least 1.5 hours and requires general anesthesia. They should be able to provide consent and have no major health issues that would complicate the use of the muscle relaxant medication. If you join the study, you will undergo standard monitoring during your surgery and help researchers learn more about the best ways to ensure safe and effective muscle relaxation.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults 18 - 75 years of age who are able to provide consent
• • Scheduled for elective surgery requiring muscle relaxation, in a supine position under general anesthesia, with an anticipated duration of at least 1.5 hours
• Exclusion Criteria:
• • Contraindication to rocuronium use
• * Comorbidities that may prolong the duration of neuromuscular blockade or alter pharmacodynamics and/or pharmacokinetics, such as:
• • Neuromuscular disease
• • Expected or known difficult airway
• • Rocuronium allergy
• • BMI \< 18.5 or \> 40
• • History of adhesive allergy
• • Upper extremity weakness, limb deformity, or absence of all or part of an upper limb
• • Patients undergoing surgical procedures requiring cardiopulmonary bypass