Spastic Paraplegia - Centers of Excellence Research Network

Launched by BOSTON CHILDREN'S HOSPITAL · Aug 12, 2024

Keywords

ClinConnect Summary

The Spastic Paraplegia - Centers of Excellence Research Network (SP-CERN) is a research study focused on improving our understanding and treatment of hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS). This study aims to collect information about different types of HSP, find reliable tests that can help diagnose these conditions, and identify potential new treatments. For this pilot study, researchers are looking to enroll 100 individuals diagnosed with hereditary spastic paraplegia type 4 (SPG4) or type 5A (SPG5A).

To be eligible for this study, participants must be male or female of any age with a confirmed clinical and genetic diagnosis of either SPG4 or SPG5A. Unfortunately, individuals without one of these specific diagnoses will not be able to participate. If you join the study, you can expect to contribute to important research that could lead to better understanding and treatment options for these conditions. This is an exciting opportunity to be part of a collaborative effort that aims to make a difference for those affected by hereditary spastic paraplegia.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female patients of all ages with a clinical and molecular diagnosis of hereditary spastic paraplegia type 4 (SPG4, SPAST) or hereditary spastic paraplegia type 5A (SPG5A, CYP7B1).
• Exclusion Criteria:
• • Not having such a diagnosis and/or not being related to such individual.