Soft Tissue Response to Different Restorative Materials Used in Implant Dentistry

Launched by HARVARD MEDICAL SCHOOL (HMS AND HSDM) · Aug 12, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating how different materials used in dental implants can affect the surrounding gum tissue in adults who need dental implants. The researchers want to find out how materials like titanium, PEEK, zirconia, and lithium disilicate impact inflammation in the gums around the implants. They will collect fluid samples from around the implants at 3 and 6 months after placement and check the health of the gums through regular dental visits to see which material leads to the least inflammation.

To participate, you need to be at least 18 years old and have missing teeth in the back of your jaw. It's important that you have good oral hygiene and healthy gums, with no bleeding or deep pockets around your natural teeth. The study is looking for individuals without certain health conditions, such as diabetes or cancer, and those who do not smoke or have recently taken antibiotics. Participants will receive dental implants made from different materials and will be monitored regularly to ensure their gum health is tracked over time.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants must be 18 years or older.
• • Participants must be edentulous with at least four missing teeth in the posterior region of the mandible or maxillae.
• • Participants must have appropriate oral hygiene and periodontal status of natural teeth, with a pocket depth of 4mm or less and no bleeding.
• • Dental implants must be fully integrated with no bone resorption or inflammation after three months of implant placement, confirmed by X-ray and clinical examination.
• • Implant placement must be into natural bone without additional procedures such as sinus lift or bone augmentation.
• • The procedure must be a standard implantation with no immediate implant placement.
• • The height of the gingiva must be at least 3mm or more.
• Exclusion Criteria:
• • Patients with systemic diseases such as malignancy, diabetes, osteoporosis, or rheumatoid arthritis.
• • Patients with a history of periodontal treatment.
• • Patients who smoke or use tobacco.
• • Patients who have received antibiotic treatment within three months prior to implantation.
• • Pregnant individuals.