Analysis of Nasopharyngeal Microbiota in Patients With Respiratory Infections

Launched by FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS · Aug 13, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the bacteria found in the throat of patients with respiratory infections, particularly in children aged 0 to 20 years. Researchers want to understand how the balance of these bacteria—known as microbiota—can affect the severity and frequency of respiratory illnesses, like colds, pharyngitis, and pneumonia. By analyzing the bacteria present during these infections, the study aims to improve our understanding of why some infections occur more frequently and how inappropriate use of antibiotics might contribute to ongoing health issues.

To participate in this trial, children must show signs of an acute respiratory infection, but they cannot have taken antibiotics or certain other treatments in the past month or two. Participants will help researchers gather important information that could lead to better treatments and prevention strategies for respiratory infections in the future. It's important to note that this study is not yet recruiting participants, so it may take some time before it begins.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age 0-20 years
• • signs and/or symptoms of acute respiratory tract infection such as cold, pharyngitis, laryngitis, tracheitis, otitis, epiglottitis, laryngotracheitis, bronchitis and pneumonia.
• Exclusion Criteria:
• • antibiotic therapies in the last 30 days
• • treatments with prebiotics or probiotics in the last 60 days (in particular containing Streptococcus salivarius)
• • hormone therapies in the last 60 days
• • local therapies in the last 60 days
• • treatments with oral cavity disinfectants in the last 30 days
• • presence of other pre-existing or ongoing respiratory pathologies
• • current severe sepsis (sepsis criteria + organ dysfunction, peripheral hypoperfusion, hypotension)