Diagnosis of Graft Pathology by TruGraf

Launched by UNIVERSITY HEALTH NETWORK, TORONTO · Aug 13, 2024

Keywords

ClinConnect Summary

This clinical trial, called "Diagnosis of Graft Pathology by TruGraf," is focused on understanding the different causes of liver issues in patients who have received a liver transplant. The main goal is to develop a new, non-invasive test called TruGraf. This test looks at certain genes in the blood to help doctors determine if there is any liver damage without needing to rely solely on traditional biopsy methods. By comparing the results from TruGraf with liver biopsy findings, researchers hope to create a tool that can more easily diagnose liver problems in transplant patients.

To participate in this study, individuals must be at least 18 years old and have received a single-organ liver transplant. They also need to be willing to provide their consent and be scheduled for a liver biopsy, either soon or already completed within 48 hours of joining the study. This trial is currently recruiting participants of all genders. If you join, you can expect to provide a blood sample that will be analyzed alongside your biopsy results, helping to improve understanding and diagnosis of liver transplant issues in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. . Single-organ Liver transplant recipients
• • 2. Male or female, age \> 18 years at the time of signing informed consent.
• • 3. Willing and able to provide informed consent.
• • 4. Patients will be undergoing liver graft biopsy (for any reason), or have had a liver biopsy within 48 hours of consent.
• Exclusion Criteria:
• • 1. Repeat transplant
• • 2. Recipient of multi organ transplantation
• • 3. Any treatment for graft rejection such as IV steroids has been given before biopsy.
• • 4. Targeted biopsies for diagnosis of malignancy.