Exploring the Characteristics of Epileptogenic Foci in Drug-Resistant Epilepsy Based on Multimodal Imaging Technology

Launched by XIJING HOSPITAL · Aug 13, 2024

Keywords

ClinConnect Summary

This clinical trial is studying patients with drug-resistant epilepsy, which means their seizures do not respond well to standard treatments. The researchers want to use advanced imaging techniques, like Magnetic Resonance Imaging (MRI) and Electroencephalograms (EEG), to better understand the areas in the brain that cause these seizures. By exploring these brain areas, the team hopes to improve the way doctors diagnose drug-resistant epilepsy and better understand how different parts of the brain work together during seizures.

To participate in the trial, you need to be at least 18 years old and have had epilepsy for at least two years, with seizures happening at least twice a month recently. You should also have tried two or more anti-epileptic medications without success. Participants will undergo various imaging tests and will not change their treatment during the study. It's important to note that individuals currently experiencing continuous seizures, pregnant or breastfeeding women, and those with certain health conditions may not be eligible. If you or a family member are interested in participating, the research team will ensure you fully understand the study and provide consent before moving forward.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Aged ≥18 years old;
• • 2. Meet the 2010 International League Against Epilepsy (ILAE) diagnostic criteria for drug-resistant epilepsy;
• • 3. Duration of epilepsy ≥2 years, with an average seizure frequency of ≥2 times per month in the 3 months prior to enrollment;
• • 4. Adequate intake of two or more anti-epileptic drugs, with no intervention in the treatment plan during the trial period;
• • 5. Capable of cooperating to complete treatment and related examination items; The patient and family fully understand and voluntarily sign the informed consent form.
• Exclusion Criteria:
• • 1. In a state of continuous epileptic seizures;
• • 2. Complicated with severe infections, cerebrovascular diseases, malignant tumors, and other diseases, accompanied by severe dysfunction of the heart, liver, kidney, or other organs, or with mental disorders, or with uncorrectable hyperglycemia, or 3.patients on long-term use of corticosteroid medications;
• • 4.Pregnant or lactating women; 5.Contraindications for PET, MR, EEG examinations; 6.Patients with examinations (with ferromagnetic metal implants in the body; high fever); 7.Participating in other clinical trials at the same time; 8.The patient or family withdraws the informed consent form.