Prevention of Chronic Lung Disease (CLD - Prevention Study)

Launched by FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS · Aug 14, 2024

Keywords

ClinConnect Summary

The Prevention of Chronic Lung Disease (CLD) study is investigating ways to identify which premature infants might be at a higher risk of developing serious lung problems within their first year of life. Researchers will look for specific biological markers in these infants that could help predict lung function issues and the potential for asthma later on. The study will focus on preterm infants born before 32 weeks of pregnancy who show signs of breathing difficulties right after birth.

Eligible participants are those who needed help breathing, such as mechanical ventilation or oxygen support, within the first 24 hours of life. If your baby qualifies, they will undergo several tests and provide various biological samples over their first year, including blood and stool samples. The goal is to gather important information that could help improve care for these vulnerable infants and reduce the risk of chronic lung disease in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Infants with gestational age \< 32 weeks with at least one of the following signs of acute respiratory failure within the first 24 hours of life:
• • need for mechanical ventilation;
• • need for noninvasive respiratory support;
• • need for oxygen administration;
• • need for surfactant administration
• Exclusion Criteria:
• • Congenital malformations
• • Neuromuscular diseases.