Preoperative Planning With PSMA-PET in Melanoma Surgery Trial

Launched by ROYAL MARSDEN NHS FOUNDATION TRUST · Aug 15, 2024

Keywords

ClinConnect Summary

The Preoperative Planning With PSMA-PET in Melanoma Surgery Trial is a study looking at a new way to help detect cancer spread (metastases) in men with malignant melanoma, a type of skin cancer. The researchers want to see if a special imaging test called PSMA PET/CT can provide better information before surgery. This study is not yet open to participants, but it aims to gather important data to improve treatment for patients.

To be eligible for this trial, participants must be men aged 18 or older who have been diagnosed with melanoma that has spread to nearby lymph nodes and who are scheduled for surgery. They should also have had a specific type of scan (FDG PET-CT) done recently as part of their regular care. However, individuals who are not fluent in English, cannot give consent, or have certain other health conditions or treatments will not be able to participate. If enrolled, participants can expect to undergo the PSMA PET/CT scan along with other assessments to help the researchers understand how well this imaging test works in planning their surgery.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Males ≥18 years of age
• • Biopsy proven first and recurrent metastatic melanoma with palpable nodal disease who have undergone a staging FDG PET-CT scan as part of routine clinical care and are scheduled for surgery for resection of the primary site
• Exclusion Criteria:
• • Patients unable to give voluntary written informed consent to participate in this study
• • Patients not willing to complete all the study assessments
• • Patients who are females
• • Patients who are taking androgen deprivation therapy (ADT) and other therapies targeting the androgen pathway, such as androgen receptor antagonists.
• • Patients who have or have previously been diagnosed with prostate cancer
• • Patients who have had Lu-177 PSMA therapy or barium studies within a period of 10 days prior to undergoing PSMA PET-CT scanning
• • Patients not fluent in English