High-dose Dual Therapy and Minocycline-cotaining Quadruple Therapy for Helicobacter Pylori Infection

Launched by SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE · Aug 16, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at two different treatment plans for a common stomach infection called Helicobacter pylori (H. pylori). This bacteria can cause problems like ulcers and is often treated with antibiotics. The study wants to compare a high-dose dual therapy to a quadruple therapy that includes a medication called minocycline. They will enroll 200 adults who have tested positive for H. pylori to see how effective these treatments are, how well patients tolerate them, and whether the bacteria show any resistance to the antibiotics used.

To participate in this study, patients need to be between 18 and 80 years old and must have a confirmed H. pylori infection. However, individuals who are pregnant, have certain serious health conditions, or have had major stomach surgery in the past cannot join. Participants will undergo some tests to check the bacteria and its sensitivity to different antibiotics. They will receive treatment and then be monitored for any side effects or complications. This trial is currently recruiting participants, and it aims to help improve treatment options for H. pylori infections in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Ability and willingness to participate in the study and to sign and give informed consent
• • Confirmed H. pylori infection
• Exclusion Criteria:
• • Pregnant and lactating women;
• • History of gastrointestinal malignancies;
• • History of previous subtotal gastrectomy;
• • Serious dysfunction of heart, liver, kidney, lung and other important organs and congenital diseases; Such as grade IV cardiac insufficiency, liver failure, uremia, respiratory failure, hemophilia, Wilson disease, etc;
• • History of hematological diseases
• • People who are allergic to drugs;
• • The guardian or patient refused to join the group;
• • Alcohol and / or drug abuse (addiction or dependence) or poor compliance judged by doctors;
• • No legal capacity or poor self-knowledge
• • administration of antibiotics, bismuth, antisecretory drugs, or Chinese herb medicine in the preceding 8 weeks