Optimization of Minocycline for Helicobacter Pylori Rescue Treatment

Launched by SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE · Aug 16, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a treatment for Helicobacter pylori (H. pylori) infection, a common bacteria that can cause stomach problems. Researchers are comparing two different ways of using a treatment called bismuth-containing quadruple therapy, which includes medications like minocycline and metronidazole. They want to find out if adjusting the doses of these medications can help eliminate the infection more effectively while causing fewer side effects.

To participate in this study, individuals must be between 18 and 80 years old and have been diagnosed with H. pylori after previous treatments that didn’t work. Participants will receive a 14-day treatment and will be monitored for how well the therapy works and how they tolerate it. It’s important to note that certain people, such as those who are pregnant, have had stomach surgery, or have serious health conditions, cannot take part in the trial. If you or a family member is interested in learning more or might be eligible, please consider discussing it with a healthcare provider.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Ability and willingness to participate in the study and to sign and give informed consent
• • Confirmed H. pylori infection and with previous treatment experience
• Exclusion Criteria:
• • subjects naive to H. pylori treatment,
• • under 18 or over 80 years old
• • history of gastrectomy
• • pregnant or lactating women
• • Previous history of tuberculosis
• • Allergy to any of the study drugs
• • severe systemic diseases or malignancy
• • administration of antibiotics, bismuth, antisecretory drugs, or Chinese herb medicine in the preceding 8 weeks