Ventilator Settings for Bronchoscopy During Mechanical Ventilation: a Randomized Controlled Study

Launched by CENTRE HOSPITALIER ARRAS · Aug 17, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how to make a procedure called fiberoptic bronchoscopy (FOB) safer for patients who are on mechanical ventilation, which is a machine that helps people breathe when they can’t do it on their own. During FOB, the machine may have trouble delivering the right amount of air because the procedure can cause increased pressure in the lungs. The study is testing new settings on the ventilator to see if they can help reduce this pressure, making the procedure easier and safer for critically ill patients.

To participate in this study, you need to be at least 18 years old and receiving mechanical ventilation due to severe breathing problems in an intensive care unit. You would also need to be under sedation and have a medical reason for needing the bronchoscopy, such as checking the airways. The study is currently recruiting participants and aims to find a better way to support patients needing this important procedure while on a ventilator. If you or a loved one are considering joining, the study team will guide you through what to expect during the trial and ensure you understand everything involved.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥18 years;
• • Acute respiratory failure requiring invasive mechanical ventilation in the intensive care unit;
• • Indication of either a fiberoptic bronchoscopy (FOB) procedure or a percutaneous tracheostomy under FOB control;
• • Patient under sedation with Richmond Agitation and Sedation Scale(RASS) ≤-2,
• • Written informed consent obtained by the patient or the patient legal representative
• Exclusion Criteria:
• • Presence of an absolute contraindication to FOB (respiratory arrest, severe acute respiratory distress syndrome (ARDS), refractory shock, uncontrolled heart rhythm disorder);
• • Patients in respiratory distress or with severe patient-ventilator desynchronies ;
• • Patients refusing FOB;
• • Pregnancy ;
• • Moribund patients (according to American Society of Anesthesiologists (ASA) Physical status score classification, class 5: high probability of death within 24 hours) or at high risk of death during the FOB procedure;
• • Patients deprived of liberty;
• • Patients under curators or guardianship.