Comparing Trypsin-Chymotrypsin and Naproxen Sodium for Post-endodontic Treatment Pain

Launched by DOW UNIVERSITY OF HEALTH SCIENCES · Aug 16, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how effective two different medications, Trypsin-Chymotrypsin and Naproxen Sodium, are at reducing pain after root canal treatment in patients who are experiencing severe tooth pain due to a condition called symptomatic irreversible pulpitis. The goal is to find out which medication works better to help patients feel more comfortable after their dental procedures, as many people avoid going to the dentist because they fear the pain that may follow treatment.

To participate in this study, you should be a healthy adult aged 18 to 45 who is scheduled for a root canal. Unfortunately, if you have certain conditions, like needing emergency dental work or having a serious health issue, you won’t be eligible. During the trial, 100 participants will be randomly assigned to receive one of the two medications after their treatment, and pain levels will be checked at various times afterward. This trial is important because it aims to improve pain management in dental care, helping patients feel less anxious about their treatments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Both male and female, healthy patients (ASA class 1).
• • Patients between the age group of 18-45 years.
• • Patients who are appointed for endodontic treatment.
• • Maxillary or mandibular teeth diagnosed with symptomatic irreversible pulpitis based on delayed responses to vitality tests.
• Exclusion Criteria:
• • Patients who will require emergency dental treatment.
• • Teeth with any form of peri-apical lesion will be excluded.
• • Patient who have taken analgesics within 24 hours prior to the treatment.
• • Patients with known hypersensitivity or allergy to any of the study medications.
• • Patients with any systemic disease such as uncontrolled diabetes, gastric ulcers, bleeding disorders, or cardiovascular problems.
• • Pregnant or lactating women and pediatric patients.